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Novel MRI Biomarkers for Monitoring Disease Progression in ALS

Amyotrophic Lateral Sclerosis | Motor Neuron Disease

Routine MRI is normal in motor neuron diseases such as ALS. However, advanced MRI techniques can provide an objective measure of degeneration (a "biomarker") by examining brain structure, wiring, chemistry, and function. We will develop and evaluate novel MRI techniques that could improve our understanding of ALS and provide a means to diagnose it sooner and monitor its progression. Importantly, we expect these techniques to improve how new drugs are tested, which may lead to the more rapid discovery of a treatment for ALS.

Each participant will have 3 MRI scans over a period of 8 months, along with neurological and cognitive evaluations. Study visits will take 2 - 3 hours. MRI is a safe technique that does not involve radiation.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Patients with a suspected or confirmed diagnosis as described in Study Populations
* For those with a diagnosis of ALS, patients will be considered with an El Escorial classification of suspected, possible, probable, probable lab-supported, and definite ALS.
* Patients 18 years of age or older
* Healthy controls over the age of 40.
* Be able to lie in an MRI machine for approximately 60 minutes

Exclusion Criteria:

* Subjects with psychiatric/CNS illnesses such as Major Depressive Disorder, Schizophrenia, and Bipolar disorder.
* Subjects with significant head injury or other neurological disease (stroke, brain tumour).
* Subjects ineligible for MRI investigation due to a pacemaker or other metallic foreign body.

Lieu de l'étude

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Sara Moradipoor, MSc

[email protected]
780-248-1805
McGill University / Montreal Neurological Institute and Hospital
McGill University / Montreal Neurological Institute and Hospital
Montreal, Quebec
Canada

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Backup Contact

Smita Patel

[email protected]
514-398-1779
Primary Contact

Natalie Saunders

[email protected]
514-398-6526
University of Calgary / Heritage Medical Research Clinic
University of Calgary / Heritage Medical Research Clinic
Calgary, Alberta
Canada

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Backup Contact

Janet Petrillo

[email protected]
403-210-7006
Primary Contact

Victoria Hodgkinson

[email protected]
403-210-7303
University of Toronto / Sunnybrook Health Sciences Centre
University of Toronto / Sunnybrook Health Sciences Centre
Toronto, Ontario
Canada

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Primary Contact

Shirley Pham

[email protected]
416-480-5618
University of British Columbia / GF Strong Rehab Centre
University of British Columbia / GF Strong Rehab Centre
Vancouver, British Columbia
Canada

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Laval University
Laval University
Quebec City, Quebec
Canada

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Primary Contact

Alexandra Simard, BSc

[email protected]
418-649-0252
Western University / London Health Sciences Centre
Western University / London Health Sciences Centre
London, Ontario
Canada

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Étude parrainée par
University of Alberta
Participants recherchés
Plus d'informations
ID de l'étude: NCT03362658