Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Parkinson Disease | Alzheimer Disease | Progressive Supranuclear Palsy | Mild Cognitive Impairment |...To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).
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Conditions de participation
-
Sexe:
ALL -
Âges admissibles:
40 and up
Critères de participation
Inclusion Criteria:
* Referring diagnosis of MCI or early dementia
* Age 40-95
* Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
* Must, in the opinion of the site investigator, be able to complete most study procedures.
Exclusion Criteria:
* Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Lieu de l'étude
Centre for Addiction and Mental Health
Centre for Addiction and Mental HealthToronto, Ontario
Canada
Contactez l'équipe d'étude
Sanjeev Kumar, MD
Tarek Rajji, MD
Toronto Western Hospital, University Health Network
Toronto Western Hospital, University Health NetworkToronto, Ontario
Canada
Contactez l'équipe d'étude
Maria C Tartaglia, MD
Baycrest
BaycrestNorth York, Ontario
Canada
Contactez l'équipe d'étude
Morris Freedman, MD
Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences CentreToronto, Ontario
Canada
Contactez l'équipe d'étude
Sandra E Black, MD
- Étude parrainée par
- University Health Network, Toronto
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT06529744