Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Colorectal Cancer | Polyp of ColonLarge (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.
We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 and up
Participation Criteria
Inclusion Criteria:
* adult ≥18 years old
* patients undergoing EMR for a large (≥20mm) colorectal LSL
* patients providing written and informed consent for study participation.
Exclusion Criteria:
* inflammatory bowel disease;
* non-elective colonoscopy;
* poor general health (American Society of Anesthesiologists classification \>III);
* coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \<50 x 109/L);
* pedunculated polyps (Paris class Ip, Isp);
* overt signs of deep submucosal invasive cancer (JNET 3);
* biopsy proven invasive carcinoma in a potential study polyp.
* Pregnant women
Study Location
Centre Hospitalier de l'Université de Montréal
Centre Hospitalier de l'Université de MontréalMontréal, Quebec
Canada
Contact Study Team
Centre Hospitalier de l'Université de Montréal
Centre Hospitalier de l'Université de MontréalMontreal, Quebec
Canada
Contact Study Team
- Study Sponsored By
- Centre hospitalier de l'Université de Montréal (CHUM)
- Participants Required
- More Information
- Study ID:
NCT06271941