Interdialytic Peritoneal UltraFiltration in HemoDialysis Patients
Hemodialysis | Peritoneal Dialysis | End Stage Renal Disease on Dialysis | Nonosmotic Sodium StorageSodium accumulates in the tissues of patients with kidney disease and impairs survival. Three-times weekly, standard hemodialysis alone cannot remove excess sodium efficiently. A sample of 10 chronic hemodialysis patients will undergo a 5-week, pilot, interventional study to test the efficacy of additional sodium removal in-between hemodialysis sessions, twice per week, for three weeks. Tissue sodium removal will be achieved with peritoneal dialysis after the surgical insertion of a peritoneal dialysis catheter. Tissue sodium removal will be assessed at the beginning and at the end of the study with sodium magnetic resonance imaging of a peripheral limb (leg). Patients will also undergo monitoring for symptoms and blood pressure throughout the study to assess the safety of this procedure.
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Conditions de participation
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Sexe:
ALL -
Âges admissibles:
18 and up
Critères de participation
Inclusion Criteria
* At least one of the following:
* Average per-session interdialytic weight gain ≥ 4.0 % of their dry weight in the last month;
* Inability to consistently achieve dry weight with the current treatment schedule;
* Need for additional HD treatments to achieve prescribed dry weight.
* Weekly HD sessions - up to three times/week
* Age ≥18 years
* Willing and able to give informed consent
Exclusion Criteria
* Contraindications to peritoneal dialysis
* Contraindications to MRI
* Uncontrolled diabetes mellitus
* Active infections
* Non-compliance to hemodialysis prescription
* Pre-study serum sodium \< 130 mmol/L
Lieu de l'étude
London Health Sciences Centre
London Health Sciences CentreLondon, Ontario
Canada
Contactez l'équipe d'étude
- Étude parrainée par
- London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT04603014