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Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting

Corneal Melting in Boston Keratoprosthesis Type I

The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 80

Participation Criteria

Inclusion Criteria:

* Candidate for KPro type I
* Capacity to give written consent
* Ability to be followed for the duration of the study

Exclusion Criteria:

* Participation in another interventional study
* Failure to wear a therapeutic contact lens due to abnormalities of the eyelids.
* Inability to give written consent

Contraindications to the KPro type I:

* Severe dryness with keratinization of the ocular surface
* Intraocular tumor
* Terminal glaucoma
* Inoperable retinal detachment
* Phthisis bulbi

Study Location

Centre Hospitalier de l'Université de Montréal
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Marie-Catherine Tessier

[email protected]
514 890-8000
Study Sponsored By
Centre hospitalier de l'Université de Montréal (CHUM)
Participants Required
More Information
Study ID: NCT03041883