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Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting

Corneal Melting in Boston Keratoprosthesis Type I

The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 80

Participation Criteria

Inclusion Criteria:

* Candidate for KPro type I
* Capacity to give written consent
* Ability to be followed for the duration of the study

Exclusion Criteria:

* Participation in another interventional study
* Failure to wear a therapeutic contact lens due to abnormalities of the eyelids.
* Inability to give written consent

Contraindications to the KPro type I:

* Severe dryness with keratinization of the ocular surface
* Intraocular tumor
* Terminal glaucoma
* Inoperable retinal detachment
* Phthisis bulbi

Study Location

Centre Hospitalier de l'Université de Montréal
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec
Canada

Contact Study Team

Study Sponsored By
Centre hospitalier de l'Université de Montréal (CHUM)
Participants Required
More Information
Study ID: NCT03041883