Proof of Concept Creatine Supplementation for Homocystinuria Study
HomocystinuriaHomocystinuria is a rare and inherited metabolic disorder, people with this condition don't have an enzyme needed to break down an amino acid called homocysteine. When the body can't break down the homocysteine made from another amino acid methionine, it becomes toxic to the heart, brain, and bones. We are constantly eating methionine, a building block of protein, so a common treatment is eating a low-protein diet with medical foods and vitamin pills. This can be hard to follow due to bad tastes and missing out on foods a person enjoys, especially in children.
The goal of this study is to provide participants with a supplement containing creatine, another amino acid related to methionine and homocysteine, and learn if it lowers homocysteine production in healthy adult men. We would ultimately like to see if creatine supplements are a potential alternate treatment of Homocystinuria in this proof of concept study, before studying individuals with the condition.
Researchers in this study want to know:
* How does the bodies digestion of isotope methionine change in breath and urine when creatine is taken in healthy young adult men?
* How do levels of homocysteine, methionine and related metabolites change in the blood when creatine is taken by healthy young adult men?
Participants will:
* Complete two (2), 8-hour study days on-site.
* Eat a lower protein diet for one (1) week before the first study day, and eat a lower protein diet with creatine supplements for one (1) week before the second study day.
* During both study days eat special hourly meals of controlled amino acids and nutrients, along with a methionine isotope. (An isotope is a stable labelled amino acid that is colourless, odorless, tasteless, and safe for consumption. In the lab we can detect this isotope in breath and urine samples collected during the study day).
* Provide samples of breath, urine and blood. (Researchers will also take body measurements (height weight), and use non-invasive tests to measure body composition and energy needs).
null
Conditions de participation
-
Sexe:
MALE -
Âges admissibles:
19 to 40
Critères de participation
Inclusion Criteria:
* Cis-male
* Men who are classified as normal body weight and BMI (18.5-25kg/m2)
* Free of any concurrent illness (cold, flu, vomiting etc.)
* Not be claustrophobic (we will place a clear hood, which can easily be removed, over your head for approximately 20 min to measure your energy expenditure)
* Not be enrolled in any other research studies (as this may affect our study results)
Exclusion Criteria:
* Men not in good health or have a metabolic, neurological, genetic, or immune disorder, including diabetes, hypoglycemia, hypertension and current or past history of kidney disease
* Men who have food allergies/sensitivities/intolerances to egg, corn, diary etc.
* Men who have current or recent past history of ingesting creatine supplements
* Men who are smokers
* Men who are following a non-traditional dietary pattern (e.g. Keto diet, Atkins diet, paleo diet, intermittent fasting, strict vegan, calorie restricted diet etc.)
Lieu de l'étude
BC Children's Hospital Research Institute, University of British Columbia
BC Children's Hospital Research Institute, University of British ColumbiaVancouver, British Columbia
Canada
Contactez l'équipe d'étude
- Étude parrainée par
- University of British Columbia
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT06495567