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Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes

Respiratory Insufficiency | Lung Injury | Mechanical Ventilation Complication | Diaphragm...

Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles. The abdominal muscles help by forcing air out of your lungs during exhalation; whereas the diaphragm, the main muscle used for breathing, contracts to get air into the lungs during inhalation. With mechanical ventilation, respiratory muscles are able to rest and recover while the breathing machine takes over; however, this may cause respiratory muscle weakness. Patients who develop weakness of these muscles may require more assistance from the ventilator and take longer to recover their ability to breathe without assistance. The impact of this phenomenon on long-term outcomes is uncertain.

The RESPIRE study is designed to characterize how respiratory muscles change during mechanical ventilation and to evaluate the impact on long term quality of life. An additional objective of this study is to examine novel measures obtained from automated functions of a ventilator, that may better predict success from weaning from mechanical ventilation.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Cases Inclusion Criteria:

• Adult patients ≥18 years of age undergoing invasive mechanical ventilation in the ICU for any reason within 36 hours of intubation

Control condition A Inclusion Criteria:

• Non-invasively ventilated patients in the ICU within 36 hours of initiating non-invasive ventilation

Control condition B Inclusion Criteria

• Non-ventilated patients admitted to the ICU receiving no respiratory support or oxygen therapy alone, including high flow nasal cannula

Exclusion Criteria:

* Patients expected to be extubated within 24 hours of screening for eligibility
* Patients who have already undergone a SBT at time of screening
* Patients with a previously diagnosed neuromuscular disorder
* Patients receiving long-term invasive mechanical ventilation (prior to current hospitalization)
* Patients who have required previously (during current hospitalization) a period of invasive ventilation in ICU of more than 24 hours
* Patients who have previously been enrolled in the study
* Patients for whom post-hospital follow-up may be challenging, e.g. those who reside overseas or who have no fixed address

Lieu de l'étude

Toronto General Hospital
Toronto General Hospital
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Rongyu (Cindy) Jin

Étude parrainée par
University Health Network, Toronto
Participants recherchés
Plus d'informations
ID de l'étude: NCT05857774