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IV Acetaminophen After Cardiac Surgery - PILOT

Delirium

Double blind double dummy of Intravenous Acetaminophen and oral acetaminophen placebo versus IV placebo versus oral acetaminophen in patients following cardiac surgery. The primary endpoint is development of Delirium during the post-operative stay.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* subjects \> 18 years of age undergoing elective aortocoronary bypass, single valve replacement or single valve and aortocoronary bypass surgery

Exclusion Criteria:

* • Refusal by surgeon for inclusion of the patient

* Requested late extubation by anesthesia or surgeon
* Intra-aortic balloon pump
* Sensitivity to acetaminophen
* Pre-operative cognitive dysfunction
* Psychiatric history with active treatment
* Parkinson's disease
* Alzheimer's disease
* Medication for cognitive decline
* History of recent seizures
* Recent history of alcohol misuse
* Creatinine clearance less than 30 ml/min

Lieu de l'étude

McGill University Health Centre
McGill University Health Centre
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

sheldon magder, MD

[email protected]
5149475918
Montreal Heart Institute
Montreal Heart Institute
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Yoan Lamarche, MD

[email protected]
514991-3845
Étude parrainée par
McGill University Health Centre/Research Institute of the McGill University Health Centre
Participants recherchés
Plus d'informations
ID de l'étude: NCT05246644