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Does increased carbon dioxide (CO2) make patients with Neurogenic Orthostatic Hypotension feel better?

Autonomic Nervous System

We are studying if increased carbon dioxide (CO2) can increase blood pressure and reduce symptoms in patients with Neurogenic Orthostatic Hypotension (NOH) and healthy volunteers. Participants will perform four active stand tests under different CO2 levels. We will monitor blood pressure, heart rate, and brain blood flow to determine which intervention is the most effective in minimizing symptoms and improving blood pressure. We will also take pictures of the blood vessels in the eye to better understand changes happening close to the brain

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Participation Requirements

  • Sex:

    Male, Female, Intersex

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:
1- NOH diagnosis OR Healthy volunteers
2- Over 18 years old
3- Non-smoking
4- Able and willing to provide informed consent.
Exclusion Criteria:
1 - Has not being diagnosed with NOH by a physician (patients only)
2 - Inability to tolerate a mask during the study
3 - Require portable oxygen at rest or with exercise
4 - Heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.

Study Location

University of Calgary
University of Calgary
Calgary, Alberta
Canada

Contact Study Team

Study Sponsored By
University of Calgary
Participants Required
More Information
Study ID: REB20-1322