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Fiber and Diet (FAD) to reduce leaky gut in healthy First Degree Relatives (FDRs) of Crohn's patients

Crohn's Disease | Diet | Prebiotics

Small gaps in the intestinal wall ("tight junctions") allow water and nutrients to pass through, while blocking the passage of harmful substances. When these gaps become loose, the gut becomes permeable ("leaky gut"). This may allow bacteria or toxins to pass into the bloodstream leading to inflammation.
We do not know yet what triggers Crohn’s disease; however we know that environmental factors (as diet) may change the gut microbes (“dysbiosis”) and when combined with “leaky gut” this can initiate chronic inflammation in susceptible people.
During this study we will assess if prebiotics (dietary fibers like oligofructose-enriched inulin) and “Low n-6 PUFA diet” can effectively reduce "leaky gut" and thus lower the risk for Crohn’s.

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Participation Requirements

  • Sex:

    Any

  • Eligible Ages:

    15 to 50

Participation Criteria

Inclusion Criteria:
• First degree relative (parent, sibling, child) of patient diagnosed with Crohn’s disease;
• Agree not to use any dietary supplements, herbal treatments, probiotics, prebiotics or dietary therapies within 1 week of starting the trial and during the study;
• Willingness to keep current physical activity during study period;
• Ability to give valid informed consent
• For females of childbearing potential and sexually active, a negative pregnancy test at screening and end-of-study, and accord to use appropriate birth control method (hormonal contraceptives, intrauterine devices, vasectomy/tubal ligation, barrier methods (condom or diaphragm), double-barrier methods or abstinence) during study period.
Exclusion Criteria:
• Use of probiotic and prebiotic supplements, fish oil, Aspirin or Advil in the last 1 week;
• Use of antibiotics in the last 2 months;
• Celiac disease, gluten intolerance/sensitivity, diabetes, irritable bowel syndrome (IBS);
• Having an active gastrointestinal infection
• Having blood and bleeding disorder, uncontrolled or unstable blood pressure;
• Having a significant chronic disorders (immune disorders, organ transplant, severe cardiac disease, renal failure, pulmonary disease, psychiatric disorder);
• Alcohol or drug abuse;
• Pregnant or lactating;
• Not able to consent to the study.

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Dr. Dieleman group

[email protected]
7804920019
Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: Pro00090125