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Does Biological Sex Influence Insulin Sensitivity and Muscle Metabolism Following High-intensity Interval Exercise?

Exercise

High-intensity interval exercise (HIIE) is a type of exercise that involves alternating periods of intense exercise with periods of rest. HIIE has been shown to improve many aspects of cardiovascular and metabolic health in a time-efficient manner (e.g., only 20 minutes per exercise session). An important health benefit of exercise is improved blood sugar control, which can help reduce the risk of metabolic diseases like type 2 diabetes. A single session of HIIE has been shown to improve blood sugar in males, but it is unknown if females achieve the same health benefit. It is also not fully understood how exercise improves blood sugar in males and females. Therefore, the purpose of this project is 1) to determine if a single session of HIIE improves blood sugar control in males and females, and 2) to evaluate if changes in skeletal muscle can explain the beneficial effects of HIIE on blood sugar.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 to 35

Critères de participation

Inclusion Criteria:

* 18-35 yrs
* VO2peak considered recreationally active as defined as 'fair' or 'good' (males: 41.6- 50.5ml/kg/min; females: 35-41.9 ml/kg/min) based on Canadian Society for Exercise Physiology (CSEP) normative fitness values.
* BMI between 18-27 kg/m2
* 1-3 structured exercise sessions/week, and not training for any specific sport
* Weight stable (within ± 2kg for at least 6 months)
* Eumenorrheic (female only), defined as menstrual cycle lengths ≥ 21 days and ≤ 35 days resulting in 9 or more consecutive periods per year)
* Non-smoker

Exclusion Criteria:

* Diagnosed with cardiovascular or metabolic disease, hyper- or hypogonadism, and/or polycystic ovarian syndrome (PCOS)
* The use of medication for managing blood glucose or lipid metabolism
* Current use of oral contraceptives or use within the last 3 months
* Irregular menstrual cycles (\<21 days or \>35 days)
* Pregnant, lactating, or menopausal
* Recreational smoking of any kind
* Inability to perform the study exercise protocols or follow the pre-trial dietary or physical activity controls
* Taking medications affecting substrate metabolism (corticosteroids or nSAIDs)
* Actively engaging in a low-carbohydrate diet (e.g., ketogenic, Atkins)

Lieu de l'étude

Goldring Centre for High Performance Sport
Goldring Centre for High Performance Sport
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Stephanie Estafanos, MSc

Étude parrainée par
University of Toronto
Participants recherchés
Plus d'informations
ID de l'étude: NCT06074003