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Exercise and Sleep in Parkinson's Disease

Parkinson Disease

This study will investigate the impact of two common exercise modalities, cardiovascular and resistance training, on sleep quality and architecture in persons with Parkinson's disease (PD), and whether these potential positive changes in sleep are associated with improvements in brain plasticity and different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT) or resistance training (RT) for 12 weeks, at least two times/week. The assessments will be performed at baseline and after training by an assessor blinded to the participants' group allocation.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    45 to 80

Critères de participation

Inclusion Criteria:

* Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 1-3);
* On a stable dosage of medication during the previous month;
* Having poor sleep quality defined as a score \> 18 in the PDSS-2(scores above this cut-off value define clinically relevant sleep disorders);

Exclusion Criteria:

* Having atypical parkinsonism, dementia or any other neurological, psychiatric or cardiovascular comorbidity affecting the ability to perform exercise;
* Presenting severe untreated obstructive sleep apnea (OSA);
* Having a Montreal Cognitive Assessment (MoCA) score \<21
* Having a Beck Depression Inventory (BDI version 2) score \>4
* Having absolute contraindications to exercise and to undergo transcranial magnetic stimulation (TMS);
* Currently are or will be enrolled in a drug or exercise trial during the duration of the study;
* Having participated in a structured exercise program \> 2 times per week in the two months prior to the enrollment in the study

Lieu de l'étude

Jewish Rehabiliation Hospital
Jewish Rehabiliation Hospital
Laval, Quebec
Canada

Contactez l'équipe d'étude

Backup Contact

Josephine Salib, MSc

450-688-9550
Primary Contact

Marc Roig, PhD

[email protected]
450-688-9550
Étude parrainée par
McGill University
Participants recherchés
Plus d'informations
ID de l'étude: NCT04558879