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Optical Correction and Visual Functions of Adults With Amblyopia

Amblyopia

Amblyopia is a developmental anomaly resulting from abnormal visual experiences in early life. Amblyopia causes reduced visual acuity in the absence of a pathology. Adult sensory systems are believed to be structurally invariant beyond early, critical periods of development. However, recent evidence suggest that visual functions in adults with amblyopia can be improved with optical correction alone. This study aims to investigate whether improvements in best corrected visual acuity and other visual functions can result following appropriate optical correction in adults with amblyopia. Functional measures relating to vision, binocular vision, and eye movements will be used to assess the efficacy of refractive correction for improving vision. This study will help us better understand the improvements in visual functions following optical correction, as well as the mechanisms underlying neuroplasticity in adults with amblyopia.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 39

Participation Criteria

Inclusion Criteria:

* 18-39 (inclusive) years of age
* Anisometropic amblyopia (difference of ≥0.50D spherical equivalent or ≥1.50D astigmatism between eyes) or mixed mechanism amblyopia (strabismus and anisometropia)
* Best corrected visual acuity (BCVA) in the amblyopic eye of 0.3 logMAR to 1.0 logMAR (inclusive)
* BCVA in the non-amblyopic eye of 0.1 logMAR or better, and an interocular VA difference of 2 logMAR lines or more
* Difference of 1.00D or more between current refractive correction and study prescription
* Good general health

Exclusion Criteria:

* Other pathological ocular anomalies known to cause reduced visual acuity
* Presbyopia (based on amplitude of accommodation)
* Inability to tolerate prescribed refractive correction in spectacles (e.g., due to aniseikonia)
* Contraindication to cycloplegic eye drops
* Currently under amblyopia treatment/therapy
* Inability to comprehend test instructions and/or provide consent
* Eccentric fixation
* \>-6.00DS of myopia in either eye with spectacles
* Bilateral amblyopia
* Presence of amblyopia that is not due to strabismus and/or anisometropia
* Presence of (current or previous) psychiatric, visual, or neurological disorders

Study Location

University of Waterloo
University of Waterloo
Waterloo, Ontario
Canada

Contact Study Team

Primary Contact

Benjamin Thompson, PhD

[email protected]
(519) 888-4567
Study Sponsored By
Centre for Eye and Vision Research
Participants Required
More Information
Study ID: NCT05394987