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Multi-modality Imaging (PCa) Using Sodium MRI and PSMA PET in Men Pre-prostatectomy

Prostate Cancer | Prostate Adenocarcinoma | Prostate Neoplasm

The study is a non-randomized, prospective trial of men scheduled for radical prostatectomy for treatment of prostate cancer as standard of care and will undergo a series of pre-operative multi-modality imaging studies. Pre-operative imaging will be correlated with actual pathology results and statistical modeling performed to determine the most informative imaging biomarkers in predicting cancer location and aggressiveness (Gleason Score).

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Conditions de participation

  • Sexe:

    MALE

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Provision of informed consent for this study
* Male, aged 18 years or older
* Pathologically confirmed prostate cancer on previous biopsy
* Suitable for and consenting to Radical Prostatectomy for treatment as standard of care

Exclusion Criteria:

* Prior therapy for prostate cancer (including hormone therapy)
* Use of 5-alpha reductase inhibitors, i.e. finasteride (Proscar) or dutasteride (Avodart) within 6 months of study start. Patients undergoing a 6-month washout period prior to study start will be eligible.
* Inability to comply with the pre-operative imaging panel
* Patients scheduled for radical prostatectomy with prostate size exceeding 65 cc
* Allergy to contrast agents to be used as part of the imaging panel
* Acute kidney injury (AKI), chronic kidney disease (CKD) Stage 4 or 5 (estimated Glomerular Filtration Rate \[eGFR\] \< 30 mL/min/1.73m2) or those on dialysis
* Post-void residual urine volume \> 150 cc (determined by post-void ultrasound)
* Hip prosthesis, vascular grafting that is MRI incompatible or sources of artefact within the pelvis
* Contraindication to MRI

* pacemaker or other electronic implants
* known metal in the orbit
* cerebral aneurysm clips

Lieu de l'étude

London Health Sciences Centre
London Health Sciences Centre
London, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Clinical Research Associate: Mena Gaed, MBBCH, MSc

[email protected]
519-685-8500
Étude parrainée par
London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
Participants recherchés
Plus d'informations
ID de l'étude: NCT04053842