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D3-Creatine and Skeletal Muscle in Older Adults

Aging | Muscle Loss

The age-related decline in muscle mass and strength are collectively referred to as sarcopenia. However, the tools currently employed to assess skeletal muscle mass (SMM) (e.g., Dual-energy Xray Absorptiometry; DXA) have substantial drawbacks, and it is known that DXA-lean soft tissue (LST) is generally not associated with health outcomes of interest. Thus, the investigators propose using a novel, non-invasive, stable isotope-labelled probe (Deuterium (D)-labelled creatine (D3-creatine; D3-Cr)) to measure skeletal muscle mass in a large cohort of older individuals. The development and employment of new methods to accurately quantify the biological substrate of sarcopenia, skeletal muscle, are critical for the measure to remain clinically relevant. The plan is to measure 350 persons from the recently established (M3) prospective cohort. There will be measurement of lean soft tissue LST and appendicular LST (aLST) using DXA and compared to D3-Cr-measured SMM (D3-Cr-SMM) at baseline, 12mo, and 24mo (2yr) of follow-up. Physical mobility will also be measured (using various instruments).

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    60 and up

Participation Criteria

Inclusion Criteria:

Participants will be considered eligible for this study if they are

* Between 60 and 80y (inclusive),
* Reside in the local (i.e., within 60km of Hamilton) community; and
* Are willing and able to provide written informed consent.

Participants must fall into one of three self-reported mobility limitations based on validated screening criteria via a structured phone interview. Potential participants will be asked whether they have any difficulty:

* Walking 800m;
* Climbing ten steps; and
* Transferring from/into a car or bus.

Response options include:

* Managing without difficulty;
* Managing without difficulty but with task modification; or
* Managing with minor difficulty.

Exclusion Criteria:

* Participants who self-report more than minor difficulty will be considered to have a mobility disability and excluded.
* Participants who cannot speak or read English will also be excluded.

Study Location

Exercise Metabolism Research Laboratory, McMaster Univeristy
Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario
Canada

Contact Study Team

Primary Contact

Stuart M Phillips, Ph.D.

[email protected]
905-525-9140
Study Sponsored By
McMaster University
Participants Required
More Information
Study ID: NCT06630949