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CREDE Study: Intraoperative Crede Manoeuver Compared to Preoperative Prolapse Reduction Stress Test to Predict Postoperative de Novo Stress Urinary Incontinence (PONSUI) at the Time of Pelvic Organ Prolapse (POP) Surgery

Pelvic Organ Prolapse | Stress Urinary Incontinence | de Novo Stress Urinary Incontinence

The CREDE pilot randomized study will compare the intraoperative Crede manoeuver (M1) to preoperative prolapse (POP) reduction cough stress test (M2) for the prediction and prevention of PONSUI. The rates of PONSUI and its effect on patient reported outcomes and quality of life will be determined among women with positive or negative tests, and those with and without concomitant anti-incontinence procedure performed. This information will help inform larger studies on the topic.

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* Anterior, uterine or apical prolapse with a POP-Q stage II or more requiring surgical correction

Exclusion Criteria:

* Stress urinary incontinence (SUI) on history
* Previous anti-incontinence surgery
* Pregnancy
* Prior urethral repair surgery (diverticulum, fistula)
* Women who do not speak or read English or French
* Isolated posterior compartment prolapse
* Geographic location preventing women to come to 6 week and 6 month appointments

Study Location

McGill University Health Centre
McGill University Health Centre
Montréal, Quebec
Canada

Contact Study Team

Primary Contact

Maryse Larouche, MD, MPH

St. Mary's Hospital
St. Mary's Hospital
Montreal, Quebec
Canada

Contact Study Team

McGill University Health Centre
McGill University Health Centre
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Maryse Larouche, MD, MPH

Study Sponsored By
McGill University Health Centre/Research Institute of the McGill University Health Centre
Participants Required
More Information
Study ID: NCT04087642