Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia
Acute Coronary Syndrome | Familial Hypercholesterolemia | NSTEMI - Non-ST Segment Elevation MI |...ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and will impact patient care and outcomes. The study will recruit patients admitted to hospital with an acute coronary syndrome, and research-based genetic testing will be conducted for known FH-causing genetic variants. The results will be returned to the patients' treating physicians. The primary endpoint will be the number of patients with a new diagnosis of FH. The secondary endpoints will be the proportion of patients who undergo intensification of lipid-lowering therapy, the lowest LDL cholesterol level achieved, and the proportion of patients reaching guideline recommended lipid targets in the 12 months after the index acute coronary syndrome.
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Conditions de participation
-
Sexe:
ALL -
Âges admissibles:
18 to 60
Critères de participation
1. Age \<60 years
AND
2. Admitted to an acute cardiac unit with either:
* A ST elevation myocardial infarction (STEMI), or
* A non-ST elevation myocardial infarction (NSTEMI)
AND
3. Maximum lipid level at the time of admission or during the prior 1 year of
* LDL level ≥4 mmol/L (154 mg/dL) if not on a statin, or
* LDL-C level ≥2.5 mmol/L (96 mg/dL) if on a statin prior to presentation, or
* Non-HDL-C ≥4.6 mmol/L (177 mg/dL) if LDL-C not available
Lieu de l'étude
Vancouver General Hospital
Vancouver General HospitalVancouver, British Columbia
Canada
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St.Pauls Hospital
St.Pauls HospitalVancouver, British Columbia
Canada
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- Étude parrainée par
- University of British Columbia
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT05218005