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The Lifestyle Exercise and Diet Trial (LEAD) 2.0

Subjective Cognitive Decline

The objective of this study is to investigate the feasibility of a virtually-delivered 6-month exercise and nutrition intervention in older adults with executive subjective cognitive decline (SCD). Feasibility will be determined by recruitment, retention, and adherence rates. Preliminary changes in cognition, physical function, and quality of life will be assessed as secondary outcomes. The study will recruit 140 participants aged 65 to 80 who report they feel that their memory or other thinking abilities are declining. Participants will be randomized into one of four study arms receiving different combinations of healthy lifestyle interventions. Assessments will be conducted virtually at baseline, post-intervention (6 months), and follow-up (12 months). All intervention sessions and assessment visits will be conducted online using the Zoom Healthcare platform and participants will log on using their own devices from home.

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Conditions de participation

  • Sexe:

    ALL
  • Âges admissibles:

    65 to 80

Critères de participation

Inclusion Criteria:

1. 65-80 years old
2. Meet criteria for executive SCD

1. Answer Yes to both following questions:

* Do you feel like your memory or thinking is becoming worse?
* Does this worry you?
2. ≥1SD above age and sex-based means on any of the sub scales of the Comprehensive Executive Function Inventory (CEFI) - Adult Version, indicative of concerns about executive function.
3. No objective cognitive impairment as indicated by:

* A global Clinical Dementia Rating (CDR) of ≤ 0.5
* A Blind Montreal Cognitive Assessment (MoCA) total score of \>17
3. Able to communicate in English
4. Residents of Quebec, Ontario, Manitoba, and Saskatchewan to facilitate concurrent intervention delivery
5. Low physical activity levels (\<75min/week of moderate/vigorous physical activity on the Get Active Questionnaire)
6. Screened safe to participate in moderate exercise using the Get Active Questionnaire or physician approval to engage in moderate intensity exercise without in-person supervision
7. Poor diet quality (below Canadian older adults' median intake of fruits, vegetables, nuts and fish, reported using our Diet Screening Questionnaire)
8. Able to participate remotely (i.e., availability of, or ability/willingness to adopt, a computer or tablet alongside high speed internet/data networks)

Exclusion Criteria:

* Dementia, stroke, or other chronic brain disease
* Chemotherapy or radiation to the head/neck in the past year
* Sensory impairments that would impede participation in the intervention or assessments
* Major psychiatric disorder
* Ongoing alcohol or drug abuse that in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures.
* Contraindications for exercise as determined by the American College of Sports Medicine criteria

Lieu de l'étude

University of Waterloo
University of Waterloo
Waterloo, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Bobby Neudorf, BSc

[email protected]
(519) 888-4567
Étude parrainée par
University of Waterloo
Participants recherchés
Plus d'informations
ID de l'étude: NCT06078748