Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents

Conditions de participation

• Sexe:

  ALL

• Âges admissibles:

  14 to 18

Critères de participation

Inclusion Criteria:

* Age 14- 18
* One of the following: Diagnosis of Major Depressive Disorder (MDD) or Persistent Depressive Disorder (PDD); or score ≥22 on the Mood and Feeling Questionnaire and confirmation of depression with the Mini International Neuropsychiatric Interview Kid (MINI Kid)
* BMI between 5-95th population percentile and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) ≤2.5 calculated using fasting blood work values (glucose and insulin)

Exclusion Criteria:

* History of primary psychotic illness
* Use of antipsychotics or mood stabilizers
* History of current substance use disorder (moderate to severe)
* Pre-diabetes or diabetes (fasting glucose ≥6.0 mmol/l or use of anti-diabetic drug)
* Evidence of impaired glucose tolerance on screening oral glucose tolerance test (OGTT)
* Use of weight, lipids, or blood pressure reducing agents
* History of liver disease or AST\>2 times upper limit of normal
* History of kidney disease
* MRI contraindications
* Positive pregnancy test
* Allergic to exogenous insulin
* Positive result on urine drug screen (participants with positive cannabis and alcohol urine drug screens may still be eligible for the study; positive drug screens for other substances will be exclusionary)