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Dissociation and addictive potential of IV ketamine

Major Depressive Disorder | Suicidal Ideation | Depressive Symptoms | Treatment Response

Many people with depression do not get better with the standard treatments. Ketamine treatment has become a strong and hopeful therapy for this kind of depression. Experts know that ketamine can help unipolar and bipolar treatment resistant depression. But, some questions remain. Ketamine treatment can make you feel disconnected from your body (dissociation effects). Some people may also abuse ketamine and develop an addiction. As such, more research is needed about dissociation effects and addiction potential. So, we are doing this study to learn more about the benefits and risks of ketamine treatment.

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Participation Requirements

  • Sex:

    Any

  • Eligible Ages:

    18 to 65

Participation Criteria

Inclusion Criteria:
Patients 18-65 years old with unipolar or bipolar TRD (TRD – baseline MADRS score = 20 and experienced at least 2 failed standard of care treatment trials of adequate dose and duration) at Misericordia Hospital will be eligible for the study. In our research center (Misericordia Hospital), TRD patients are referred to our service as outpatients by other clinicians in Edmonton catchment area.
Exclusion Criteria:
Exclusion criteria includes: patients not medically eligible for IV ketamine treatment. This includes reporting any active substance abuse, psychosis, serious uncontrolled medical condition, previous negative reaction to ketamine or esketamine, currently pregnant or breastfeeding

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Study team

[email protected]
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Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: Pro00163555