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Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO)

Bacterial Sexually Transmitted Diseases

There is a growing epidemic of the bacterial sexually transmitted infections (STIs) syphilis, chlamydia and gonorrhea worldwide; similarly concerning trends have been noted in Canada, where increases of over 160% have been seen in bacterial STIs over the last decade. In Canada, gay, bisexual, and other men who have sex with men (gbMSM) - including those living with HIV - are disproportionately impacted by bacterial STIs5,6These dramatic increases in bacterial STIs, the potential development of serious complications including AMR, and waning effectiveness of the promotion of conventional STI prevention tools (e.g. condoms), signals the need for novel STI prevention strategies and tools to mitigate STI-related complications. A rigorous randomized controlled trial will be conducted to compare STI PrEP vs. STI PEP and definitively assess the efficacy, safety, antimicrobial resistance profiles and costs associated with doxycycline-based STI prevention.

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Conditions de participation

  • Sexe:

    MALE

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

1. Males, ≥ 18 years of age;
2. Any sexual activity (i.e. oral sex, insertive or receptive anal sex, with or without a condom) with more than one male partner in the preceding 12 months;
3. Intention to remain sexually active with more than one male partner in the next 12 months;
4. At least one prior episode of a previously diagnosed and adequately treated syphilis, gonorrhea or chlamydia infection within 12 months prior to screening.

Exclusion Criteria:

1. Known allergy to doxycycline or tetracyclines;
2. Existing chronic or intermittent tetracycline or doxycycline use (e.g. for chronic osteomyelitis, acne).
3. Use of medications which could lower doxycycline levels, including barbiturates, phenytoin and carbamazepine.
4. Individuals currently using isotretinoin;
5. Any individual capable of becoming pregnant.

Lieu de l'étude

Sheldon Chumir Centre
Sheldon Chumir Centre
Calgary, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Grace Kwon

[email protected]
St. Michael's Hospital
St. Michael's Hospital
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Reva Persaud

[email protected]
Backup Contact

Stanley Onyegbule

[email protected]
The Ottawa Hospital
The Ottawa Hospital
Ottawa, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

TBA

BC Centre for Disease Control
BC Centre for Disease Control
Vancouver, British Columbia
Canada

Contactez l'équipe d'étude

Primary Contact

Ramin Azmin

6047075617
McGill University Health Centre
McGill University Health Centre
Montréal, Quebec
Canada

Contactez l'équipe d'étude

Backup Contact

Turna Hortoglu

[email protected]
Primary Contact

Nathalie Paisible

[email protected]
St. Joseph's Healthcare Hamilton
St. Joseph's Healthcare Hamilton
Hamilton, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Kelly Waters

Étude parrainée par
British Columbia Centre for Disease Control
Participants recherchés
Plus d'informations
ID de l'étude: NCT04762134