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Spotting and Managing Adult Repeated Traumas in the Brain

Brain Injury Traumatic Mild

Emerging evidence suggests that concussions (a type of mild traumatic brain injury; mTBIs) may cause chronic neurological disturbances with effects lasting beyond 20 years, changing brain structure and nearly doubling the risks of developing dementia into old age. Yet diagnoses remain notoriously difficult, gender differences are poorly understood, and negligible therapies exist to manage and treat these long-term effects.

This project proposes using a combination of NeuroTracker (a promising software-based cognitive assessment and intervention for mild TBIs), with the latest MRI techniques and blood-based biomarkers of brain function, to provide unprecedented assessment sensitivity of long-term concussion effects, comparing older male and female adults, with and without a history of concussion. Additionally, NeuroTracker will be used as a therapeutic intervention to improve outcomes in adults with histories of concussion, with the combined assessments measuring efficacy pre-post training.

This project aims to comprehensively understand the impacts of mild brain traumas into later life, via both physical and functional biomarkers of brain health. It will also validate the value of NeuroTracker as an accessible training intervention for recovering cognitive functions impacted by earlier-life concussions.

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Conditions de participation

  • Sexe:

    ALL
  • Âges admissibles:

    60 and up

Critères de participation

Inclusion Criteria:

* It will be based on age (60+ years) and history of concussion (with the most recent concussion occurring at least one year prior to the study). Consistent with the literature, the history of concussion will be determined by interviewing participants about their experience with each experience of concussion (e.g. how was the injury sustained (sports injury, vehicle accident, etc.), how long has it been since the injury, did they experience a loss of consciousness during the event, how was their concussion diagnosed, what were their symptoms and when did the symptoms resolve).

The interview will also gather information on age, sex, gender, education, occupation, and medical history (e.g. mood, medications). These variables will be coded and included in analyses, as appropriate. For example, years of education and years since the most recent concussion can be used as covariates.

Exclusion Criteria:

* Include the presence of a diagnosed neurological disorder (e.g. Mild Cognitive Impairment, Alzheimer's disease, Parkinson's disease), history of severe psychiatric disorder (e.g. schizophrenia), or any condition or medication that could affect cognition (e.g. psychotropic, anticholinergic drugs). Exclusion criteria also screen out the presence of any diagnosed visual impairment that could impede NeuroTracker training (i.e. severe colour blindness, monocular vision, blindness), and contraindications for MRI (e.g. metal implants).

Lieu de l'étude

Faubert Lab
Faubert Lab
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Eduardo Lugo Lab Manager, PhD

[email protected]
1-514-441-9197
Backup Contact

Jocelyn Faubert Principal Investigator, PhD

[email protected]
1-514 343-6111
Christie Lab
Christie Lab
Victoria, British Columbia
Canada

Contactez l'équipe d'étude

Primary Contact

Brian Christie Co-Investigator, PhD

[email protected]
1-250-472-4244
Jodie Gawryluk
Jodie Gawryluk
Victoria, British Columbia
Canada

Contactez l'équipe d'étude

Primary Contact

Jodie Gawryluk Co-Investigator, PhD

[email protected]
1-250-721-7549
Étude parrainée par
Université de Montréal
Participants recherchés
Plus d'informations
ID de l'étude: NCT07025317