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Threonine Requirement in Adults >60 Years of Age

Healthy | Aging

Threonine is an essential amino acid and must be obtained from the diet. The body's capacity to maintain adequate mucin synthesis is directly related to the bioavailability of certain amino acids, including threonine, serine and proline (1). Moreover, the rate of mucin synthesis has been demonstrated to be directly related to the availability of dietary threonine in healthy rats (2) and piglets (3,4). Intestinal inflammation is known to increase gastrointestinal threonine uptake and mucin synthesis in enterally fed minipigs (5). Additionally, in animals, mucin function/barrier has been shown to decline with age, leaving them more susceptible to bacterial penetration. Thus, with advancing age (6), a higher dietary supply of threonine may be needed for maintaining intestinal mucosal health. Despite this, the current threonine requirement is based on studies conducted exclusively in young adults. Thus, there is a need to determine the threonine requirement directly in older adults.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    60 to 90

Critères de participation

Inclusion Criteria:

* Consent provided
* Aged 60 to 90 years old
* In good general health as evidenced by medical history, physical health and blood draw
* Fasting blood glucose, hemoglobin A1c (HbA1c), urea, creatinine
* Willingness to participate in the study.
* BMI \<30 kg/m2.

Exclusion Criteria:

* Presence of chronic disease and/or acute illness known to affect protein/amino acid metabolism (e.g. HIV, diabetes, cancer, liver or kidney disease, acute cold or flu)
* Taking medications known to affect protein/AA metabolism (e.g. steroids)
* Inability to tolerate the diet (i.e. allergy)
* Significant weight loss during the past month or consumption of weight reducing diets.
* Significant caffeine consumption (\>2 cups per day)
* Significant consumption of alcohol (\>1 drink per day i.e. 1 beer or ½ glass of wine).
* Unwilling to have blood drawn from a venous access, or using a ventilated hood indirect calorimeter for the purposes of the study.

Lieu de l'étude

The Hospital for Sick Children
The Hospital for Sick Children
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Alyssa Paoletti, BSc, MSc

[email protected]
416-813-5744
Backup Contact

Mahroukh Rafii, BSc.

[email protected]
416-813-7454
Étude parrainée par
The Hospital for Sick Children
Participants recherchés
Plus d'informations
ID de l'étude: NCT06225648