Skip to content

DECT for Differentiating Intracerebral Hemorrhage From Contrast Extravasation

Stroke, Ischemic | Tomography, X-Ray Computed

The goal of this clinical trial is to investigate the use of DECT (Dual-Energy Computed Tomography) in patients with acute ischemic stroke who receive an intervention (thrombolysis or thrombectomy). The main questions to answer are:

1. Can DECT more accurately differentiate hyperdensities as intracranial haemorrhage (ICH) or contrast extravasation compared with single-energy CT (SECT)?.
2. Will DECT lead to better care for patients with AIS who receive intervention and have post-procedural hyperdensities?

Patients who receive intervention for acute ischemic stroke (AIS) receive a SECT at 24 hours as standard of care to determine if ICH is present. In the current study, a DECT will be done in addition to the SECT. Followup imaging (SECT or MRI) will be done at 72 hours to determine if the hyperdensity was indeed ICH. The accuracy of DECT for differentiating ICH from contrast extravasation will be compared.

null

Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Patients greater than or equal to 18 years of age presenting with acute ischemic stroke (AIS) that are candidates for 1) thrombolysis (tPA) and/or 2) endovascular thrombectomy (EVT)

Exclusion Criteria:

* Patients who are not candidates for tPA:

Intracerebral Hemorrhage on CT Ischemic Stroke within 3 months, Severe head trauma within 3 months Acute head trauma GI Malignancy or BI bleed within 21 days Coagulopathy (Platelets \<100,000/mm3, INR \>1.7, aPTT \>40s, PT\>15s) Anticoagulation (thrombin inhibitors, factor Xa inhibitors, low-molecular weight heparin) History of intracranial hemorrhage Intra-axial neoplasm Infective endocarditis Aortic Arch Dissection Patient receiving IV aspirin Patient receiving IV abciximab

* Patients who are not candidates for EVT:

No large vessel occlusion on CT angiogram Baseline Modified Rankin Scale \>3 No significant perfusion mismatch

Lieu de l'étude

Health Sciences Center
Health Sciences Center
Winnipeg, Manitoba
Canada

Contactez l'équipe d'étude

Backup Contact

Zohaib Siddiqi, MD

[email protected]
2047893996
Primary Contact

Jai Shankar, MD

[email protected]
2047893996
Étude parrainée par
University of Manitoba
Participants recherchés
Plus d'informations
ID de l'étude: NCT05675774