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Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States

Physical Inactivity | Dietary Protein | Resistance Exercise | Amino Acids

Developing tools to detect when our bodies are more resistant towards protein synthesis is valuable for identification of when someone may be at risk of losing body or muscle mass such as with aging or certain diseases. The current study aims to refine our previous breath test method to be more effective at measuring changes in how the body processes protein in different situations, such as resting, reducing physical activity, and doing resistance exercise. We hypothesize that using a lower amount of dietary amino acids in our breath test will be effective at detecting lower amounts of amino acids used after exercise, and a greater amount with step reduction compared to normal activity levels

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 to 35

Critères de participation

Inclusion Criteria:

* Healthy young (age: 18-35 years)
* BMI between normal to overweight (18.5-29.9 kg/m2)
* if oral contraceptive (OC) user, must be on monophasic OCs for at least 3 months prior to study
* if non-OC user, then must have regular menstrual cycles (length: 25-35 days) for at least 3 months prior to study and at least 6 months off of OCs

Exclusion Criteria:

* Chronic disease diagnosis (cardiovascular, thyroid, diabetes)
* Current or recent remission of cancer
* Regular use of NSAID (except low-dose aspirin), anticoagulants
* Use of prescription drugs that would impact muscle protein synthesis (e.g., Statins, Lithium, ADHD medication, etc..)
* Insertion of intrauterine device (IUD) - exception: copper
* Smoking
* Use of illicit drugs (growth hormones, testosterone)

Lieu de l'étude

Goldring Centre for High Performance Sport at the University of Toronto
Goldring Centre for High Performance Sport at the University of Toronto
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Backup Contact

Hugo JW Fung, PhD (c)

[email protected]
6472098764
Primary Contact

Daniel R Moore, PhD

[email protected]
416464088
Étude parrainée par
University of Toronto
Participants recherchés
Plus d'informations
ID de l'étude: NCT06209424