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A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

Propionic Acidemia

The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).

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Participation Requirements

  • Sex:

    ALL
  • Eligible Ages:

    1 and up

Participation Criteria

Inclusion Criteria:

* Participated in Study mRNA-3927-P101.
* Completed the EOT Visit in Study mRNA-3927-P101 within 10 days of first dose of mRNA-3927 in current study.

Exclusion Criteria:

* Not expected to receive clinical benefit from continued mRNA-3927 administration, in the opinion of the Investigator.
* Any clinical or laboratory abnormality or medical condition that, at the discretion of the Investigator, may put the individual at increased risk by participating in this study.
* History of liver and/or kidney transplant.

Study Location

Hospital For Sick Children
Hospital For Sick Children
Toronto, Ontario
Canada

Contact Study Team

Study Sponsored By
ModernaTX, Inc.
Participants Required
More Information
Study ID: NCT05130437