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Intravenous Acetaminophen After Cardiac Surgery - Definitive Study

Post-cardiac Surgery | Post-Op Complication | Post Operative Pain | Post Operative Delirium

Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

greater or equal to 18

* elective cardiac surgery
* stable pre-operative
* aorto-coronary bypass with or without 1 valve replacement.

Exclusion Criteria:

Refusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment

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Lieu de l'étude

University of Ottawa
University of Ottawa
Ottawa, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Bernard McDonald, MD MSc

[email protected]
613-612-5412
University of Laval
University of Laval
Quebec City, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Siamak Mohammadi, MD

[email protected]
1 418-656-4717
Trillium Health Centre
Trillium Health Centre
Mississagua, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Bill Wong, MD

[email protected]
905-848-7178
Universite Montreal
Universite Montreal
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Yoan Lamarche, MD, PhD

[email protected]
514 991-3845
University of British Columbia
University of British Columbia
Vancouver, British Columbia
Canada

Contactez l'équipe d'étude

Sunnybroook Health Centre
Sunnybroook Health Centre
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Neill Adhikari, MD MSc

[email protected]
416-480-4522
University of Manitoba
University of Manitoba
Winnipeg, Manitoba
Canada

Contactez l'équipe d'étude

Primary Contact

Rakesh Arora, MD PhD

[email protected]
2165082112
McGill Universtiy Health Centre
McGill Universtiy Health Centre
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

SHELDON magder, MD

[email protected]
5149475918
Backup Contact

Rayhaneh Rahgoshai, BA

5149341934
Étude parrainée par
McGill University Health Centre/Research Institute of the McGill University Health Centre
Participants recherchés
Plus d'informations
ID de l'étude: NCT06613178