Skip to content

Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)

Trapeziometacarpal Osteoarthritis

Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life. Although corticosteroids injections are a typical treatment, their effectiveness has been challenged, and side effects have been reported. Recent studies suggest that saline injections, usually considered inactive, might be a viable treatment option. The primary goal of this study is to compare the effectiveness of saline injections versus corticosteroids injections in reducing TMO-related pain and improving hand function. In this study, 40 people with TMO will be randomly assigned to receive either a corticosteroids or a saline injection, without them or the doctors performing the injection knowing which one was administered (double blind). If saline injections prove more effective, they could provide a less harmful and cheaper therapeutic alternative for TMO patients.

null

Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* aged ≥18 years
* diagnosis of TMO was confirmed by X-ray
* suffering from pain at the base of the thumb
* the attending physician deems that an intra-articular corticosteroid injection would be beneficial, rather than opting for other types of intervention such as surgery
* can read, understand and respond in French or English.

Exclusion Criteria:

* having received one or more corticosteroid injections in the last 12 months or surgery on the affected thumb;
* suffering from painful thumb caused by a trauma (e.g., fracture, sprain), rheumatoid arthritis, or De Quervain's tendonitis; and
* being unable to provide informed consent due to physical or mental incapacity.

Study Location

Centre Hospitalier de l'Université de Montréal - Physiatry
Centre Hospitalier de l'Université de Montréal - Physiatry
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Dr Luong

[email protected]
514-890-8000
Centre Hospitalier de l'Université de Montréal - Chirurgie plastique
Centre Hospitalier de l'Université de Montréal - Chirurgie plastique
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Dr Harris

[email protected]
514-890-8000
Study Sponsored By
Université du Québec à Trois-Rivières
Participants Required
More Information
Study ID: NCT06401317