Effect of Polyphenol Supplementation on Hepatic Steatosis and Vascular Compliance

Conditions de participation

• Sexe:

  ALL

• Âges admissibles:

  12 to 18

Critères de participation

Inclusion Criteria:

* Aged 12 to 18 years
* BMI percentile \> 85th for age and sex
* Diagnosis of hepatic steatosis on imaging (ultrasound or MR).
* Diagnosis of hepatic steatosis, NASH, or fibrosis on liver biopsy.
* Elevated alanine aminotransferase (ALT) enzyme level.
* Index of hepatic steatosis 8xALT/AST + BMI (+2 for girls) \> 30.

Exclusion Criteria:

* Known chronic systematic diseases
* Any other serious conditions which, according to the doctor's judgment, would prevent compliance and safe participation in the study until completion.

Exclusion criteria to be validated when contacting the participants and their parents/tutors:

* Being pregnant.
* Taking all kinds of prescription or over-the-counter natural health products/natural supplements/vitamins on an ongoing basis or within the next four months, excluding vitamin D.
* Weight loss of 5% to 10% of the usual weight in the last six months before recruitment or weight change of 5% in the last three months.
* Alcohol consumption \> two drinks/day or \> one day/week.
* Known peanut allergy and/or to the medicinal ingredients contained in the active polyphenol supplement: elderberry, haskap, black chokeberry, blueberry, blackcurrant.
* Any contraindications for MRI.