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Study of BMS-986497 (ORM-6151) in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Myelodysplastic Syndrome | Acute Myeloid Leukemia

The purpose of this study is to assess the safety, tolerability, drug levels, drug efficacy and determine the recommended dose of BMS-986497 in participants with relapsed or refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Adults with primary or secondary relapsed and/or refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
* Detectable levels of cluster of differentiation 33 (CD33) expression.
* Failed alternative therapies with established benefit.
* Eastern Cooperative Oncology Group (ECOG) performance status ≤2 and adequate organ function.

Exclusion Criteria:

* Acute Promyelocytic Leukemia.
* Clinically active central nervous system leukemia.
* Active malignant solid tumor.
* Pregnant or breastfeeding.
* Other protocol-defined inclusion/exclusion criteria apply.

Lieu de l'étude

Local Institution - 0002
Local Institution - 0002
Toronto, Ontario
Canada

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Primary Contact

Site 0002

Jewish General Hospital
Jewish General Hospital
Montreal, Quebec
Canada

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Primary Contact

Sarit Assouline, Site 0003

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Étude parrainée par
Bristol-Myers Squibb
Participants recherchés
Plus d'informations
ID de l'étude: NCT06419634