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Nitrate Mouth Rinse and the Oral Microbiome

Nitric Oxide | Oral Microbiome

The study is aimed to determine if changes to the oral microbiome occur after the use of a nitrate rich mouth rinse. Participants with be asked to use either a controlled (water) mouthrinse once daily for 2 weeks while maintaining normal oral hygiene practices, or use the nitrate rich mouthrinse once daily for 2 weeks.

Primary Outcome measures:

-changes in the composition of the oral microbiome

Secondary Outcome measures

* Blood Pressure
* Salivary Nitric Oxide Levels

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 to 40

Critères de participation

Inclusion Criteria:

* You are between the ages of 18 and 40. Have no uncontrolled systemic diseases.

Participants with mild chronic conditions such as:

* Asthma
* Type 1 Diabetes Mellitus

Exclusion Criteria:

* You are under the age of 18.
* You have uncontrolled systemic diseases, or acute infections.
* You are taking prescription, antibiotics, probiotics, or antimicrobial mouthrinses.
* You have a documented true allergy (i.e Hives, Swelling of lips/throat) Soy, Nuts, Seeds, Dairy, Egg products, Fish/Shellfish or Wheat.
* The presence of acute or chronic oral conditions including:

* Herpes Simplex Virus (recent cold sores)
* Stomatitis
* Oral Lichen Planus
* Angular Cheilitis
* Candidiasis
* Necrotizing Gingival Diseases
* Other inflammatory or infectious pathologies
* Active dental caries "cavities"
* Any other periodontal diagnosis other than 'Healthy Periodontium' or localized gingivitis

Lieu de l'étude

Dalhousie University
Dalhousie University
Halifax, Nova Scotia
Canada

Contactez l'équipe d'étude

Backup Contact

Leigha Rock

[email protected]
9024948864
Primary Contact

Jacob P Smith, DDS

[email protected]
9024836581
Étude parrainée par
Dalhousie University
Participants recherchés
Plus d'informations
ID de l'étude: NCT06588049