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Oral 'Breath Test' to Measure Anabolic Sensitivity in Young and Older Adults at Different Activity Levels

Aging | Sarcopenia | Dietary Protein | Sedentary Behavior | Amino Acids

Recent work in the investigators laboratory has examined the ability of a non-invasive 13CO2 breath-test to assess differences in amino acid oxidation rates and net balance in young healthy males following protein feeding and resistance exercise. The investigators aim to test the efficacy of this non-invasive 13CO2 breath-test to assess for differences in anabolic sensitivity between young and older adults following an acute period of habitual and reduced physical activity.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 80

Participation Criteria

Inclusion Criteria:

* Healthy young (age: 18-35 years) or older (age: 60-80 years) adults
* Average daily step-count \>7,000/day
* BMI between normal to overweight (18.5-29.9 kg/m2)

Exclusion Criteria:

* Regular use of nonsteroidal anti-inflammatory drugs (with the exception of daily low-dose aspirin)
* Use of anticoagulants
* Use of a walker, cane, or assistive walking device
* Current or recently remised cancer
* Infectious or gastrointestinal disease
* Inability to comply with study protocol (e.g., \>2,000 steps/day during Step-Reduction Phase)
* Regular tobacco use
* Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
* Diagnosed chronic illness (e.g. type 2 diabetes, heart disease, thyroid disease)
* Pregnant
* Hormonal Replacement Therapy

Study Location

Goldring Centre for High Performance Sport at the University of Toronto
Goldring Centre for High Performance Sport at the University of Toronto
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Daniel R Moore, PhD

[email protected]
416-946-4088
Backup Contact

Hugo Fung, MSc

[email protected]
Study Sponsored By
University of Toronto
Participants Required
More Information
Study ID: NCT05216809