Lower limb complications in hemodialysis patients
Diabetes | Blood Pressure | Hemodialysis | Dialysis | Kidney Disease | Leg AmputationCardiovascular disease is common among people with kidney failure. Though often not recognized, these circulatory problems often affect the blood vessels of the legs resulting in difficulty walking, foot wounds, and in some cases, amputation. However, we do not have accurate screening tests to identify circulatory problems at an early stage, before complications develop.
We propose that the smaller blood vessels in the muscle could be tested to detect circulatory problems before complications develop. Before we test whether these novel tests can prevent complications from poor leg circulation, we will first use this study to see if these tests are acceptable to patients and practical to do.
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Participation Requirements
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Sex:
Any -
Eligible Ages:
18 and up
Participation Criteria
Inclusion Criteria:
Started hemodialysis within last 6 months or have severe kidney disease approaching kidney replacement/dialysis, have at least one upper and lower limb available for measurements (arm and leg), and able to lie down on your back and on your side.
Healthy controls: adults (age 18 years or older), non-smokers, no history of cardiovascular disease (e.g. heart disease), no symptoms of cardiovascular disease (e.g. chest pain), no diabetes or kidney disease, and resting blood pressure is lower than 140/90 mmHg.
Exclusion Criteria:
-Have a severe blockage in the arteries of the lower extremities causing pain at rest or nighttime
-Have severely infected/dead tissue in lower limbs or wounds
-Have an acute kidney injury (i.e. short duration) and it is expected that you will recover your kidney function
Study Location
University of Alberta
University of AlbertaEdmonton, Alberta
Canada
Contact Study Team
- Study Sponsored By
- University of Alberta
- Participants Required
- More Information
- Study ID:
Pro00115743