Investigating the Effects of Nabilone on Endocannabinoid Metabolism

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  19 to 65

Participation Criteria

Inclusion Criteria:

* Aged 19-65 years old. For safety reasons, we will ask participants to provide photo ID showing birthdate, in order to verify age.
* The ability to tolerate complete dosing regimen of nabilone (2mg titrated, 1 week course)
* Able to sign and date informed consent form.
* Willing and able to complete study as described in protocol

Exclusion Criteria:

* Serious, unstable medical condition including but not limited to cerebrovascular, renal, hepatic and coronary heart disease;
* Coagulation/Blood Disorders or use of anticoagulant medication
* Past or current neurological illness or head trauma;
* Lifetime diagnosis of DSM-5 Axis I psychiatric conditions including mood, anxiety, eating, somatoform and/or psychotic disorders and substance abuse and/or dependence;
* Suicidality or history of suicide attempts;
* Family history of psychotic disorders (first degree relative with a psychotic disorder);
* Current use (\~30 days) of drugs of abuse that may affect the CNS, including cannabis;
* Tobacco dependence (Fagerstrom Test for Nicotine Dependence \>4);
* Pregnancy or breastfeeding;
* Presence of metal objects in the body or implanted electronic devices, that preclude safe MR scanning;
* Claustrophobia;
* Known sensitivity to marijuana or other cannabinoid agents;
* Are on medications known to interact with nabilone such as: diazepam, sodium secobarbital, alcohol, codeine, any medications that affect mental and/or psychomotor function;
* Positive during drug screening for drugs of abuse;
* Exposure to radiation \<20 mSv in the last 12 months and a number of PET scans that, including the number of PET scans under this protocol, will bring the total to more than 8 PET scans/lifetime, exceeding permissible limit for subjects participating in research set by Brain Health Imaging Centre Guideline;
* Participant has any other problem that, in the investigators opinion, would preclude participation in the trial;