Semaglutide (Ozempic/Wegovy®) seems promising at controlling appetite and reducing weight, but how it affects the way our bodies burn calories is still a debate. We are doing a study with 20 people who have obesity and type 2 diabetes. They will use semaglutide once weekly for 6 months, and we will evaluate how their bodies use energy in different situations, such as resting, exercising, eating, and sleeping. We will also explore body composition (e.g., muscle and fat) to determine if semaglutide can prevent the body from slowing down its energy use after weight loss. Our findings may contribute to the development of more personalized treatments, particularly for individuals who do not respond well to conventional treatments.

As CPIN learns from patients, the team will make data and findings available aiming to mobilize knowledge that informs and transforms practice, clinical care and decision making for better and more equitable health outcomes, especially for people with complex and/or unmet needs due to multiple, intersecting determinants affecting their health including linguistic minority status.

This study, called CONVERGE-HF, is looking at a Health Canada approved drug called Vericiguat to see if it can help people who have heart failure and some memory problems. The study will compare Vericiguat to the usual heart failure medications people get. The researchers want to see how well Vericiguat works by looking at brain and heart images, blood tests, physical and mental abilities, quality of life, and any health problems that come up. Participants will take Vericiguat or the usual treatment for approximately 6 months.

We are interested in understanding how the environment you live in, your social circumstances, cultural, and economic conditions can impact your mental well-being and your child’s brain growth. We are especially curious about how these social circumstances might influence your body during pregnancy and your child after birth. We’d like to explore this fascinating connection further. The purpose of this study is to evaluate whether: • Mothers’ social living conditions influence the tiny organisms in the gut of the mother and the child • These tiny organisms in the gut explain how maternal social circumstances influence mother’s mental health and child’s neurodevelopment.

A disruption to the balance within our microbiome (the good bacteria present in our bodies) can lead to infection. Part of the microbiome is composed by phages. Phages are viruses that multiply inside the bacteria, killing them. This study is gathering information through urine samples regarding the differences in the number of phages on the surface of bacteria between acute cystitis and asymptomatic bacteriuria. To visualize phages, we will use a special microscope called helium ion microscope.

This pilot RCT is critical to test acceptability, assess logistics, optimize the design, and build the capacities for a full-scale RCT. Our multicenter pilot randomized controlled trial (RCT) will address the following research question: is it feasible to conduct a full-scale multicenter RCT to assess the comparative-effectiveness of a virtual home-based pre-habilitation versus usual care for kidney transplant candidates?

The Surgical Ablation of Atrial Fibrillation Efficacy (SAFE) trial will assess whether concomitant surgical ablation of AF decreases the long-term risk of admission for heart failure in patients with a history of non-permanent AF undergoing cardiac surgery for another indication.

This study is being done to learn more about a medicine called erenumab in children and adolescents with chronic migraine. This study will see if erenumab prevents migraine, is safe, and whether it causes any side effects. This study will also look at what doses of erenumab are safe and effective for children and adolescents to take. To do this, erenumab will be compared to placebo for the initial 12 weeks of treatment. The placebo will look like erenumab but it will not contain active ingredients. There is also an optional 40 week extension phase during which all participants will receive erenumab. Participants in the study will come to the Stollery for monthly study visits.

A multidisciplinary pain clinic includes researcher-scientists, teaching staff, and patient care related to acute and chronic pain. There is only one university-based outpatient orofacial multidisciplinary pain clinic (OMPC) located in Edmonton, Alberta, Canada, that manages patients with medically complex conditions and includes dental specialists and dentists as part of the expert team. The objective of this study is to explore the characteristics of Edmonton’s OMPC, and to analyze and quantify the delivery, diagnosis, and treatment of orofacial multidisciplinary pain clinic service. Also, to determine a potential association between chronic orofacial pain symptoms and psychological distress.

Our study aims to investigate the health benefits of traditional kefir, a fermented dairy drink, especially in metabolic conditions. Unlike commercial kefir, traditional versions with a mix of bacteria and yeast seem more beneficial. In mice, traditional kefir was better than commercial ones in high-fat/cholesterol conditions. Our pilot trial in humans showed promising results, leading us to explore further in people with high blood glucose. We want to see if traditional kefir improves vascular health and immune outcomes in both females and males over 12 weeks.