There is an urgent need to understand the role of therapeutic dietary interventions on the treatment of inflammatory bowel disease (IBD). This study explores the efficacy of a Therapeutic Dietary Intervention (TDI) compared to conventional management (CM) to induce steroid-free clinical remission at week 13 in patients with active, mild-to-moderate Crohn’s Disease. In this 3-year study, conducted at the University of Calgary and the University of Alberta, eligible participants will be randomly allocated in a 2:1 ratio to either the intervention group (CD-TDI) or conventional management (CM) alone (i.e., control group) for 13-weeks. Blood and stool samples will be collected to assess the effect of the dietary intervention.

The FOCUS study is being done to see if a medicine called semaglutide can reduce the risk of retinopathy progression in people with type 2 diabetes.

People with chronic heart failure are often prescribed medications to help manage their condition. This study is testing how well a drug called finerenone works and how safe it is for people with heart failure who cannot take a class of medications known as mineralocorticoid receptor antagonists (MRAs). MRAs are commonly used in treating heart failure, but some patients can't use them due to side effects or other health issues. This study is looking at whether finerenone which is a newer MRA medication could be a good alternative for those patients.

The purpose of this study is to investigate the use of portable oxygen during exercise in individuals with fibrotic interstitial lung disease who become hypoxemic (low oxygen in the blood) during exertion. Individuals will be allocated into a control group (no oxygen provided), or an intervention group (portable oxygen concentrator to be used during exercise) for 8 weeks. Measurements of exercise tolerance, blood vessel function, inflammation, and heart function will be taken at baseline, at the end of the intervention, and 2 weeks after the intervention.

To scale up and implement the CPIN system, thereby improving how to engage in practice based digital patient communication, education and collection of patient experience measures and feedback. Information needs to inform patient education and communication and health services in practices and regions across Canada will also be improved by this study. We will continue to implement the CPIN system using an iterative cycle of testing and improving our intervention, to contribute to a learning health system for primary care and health system leads at all levels.

The main objective is to determine whether our virtual reality cognitive behavioral therapy (VR-CBT) therapy motivates people with social anxiety disorder (SAD) to engage with and pursue their group therapy. As part of this objective, we wish to evaluate how our VR-CBT addresses the barriers of patient adherence plus how the VR application might be improved for usage by the patients. This study aims to recruit 10 patients with SAD to investigate the effects of VR-CBT as a preparatory exposure tool for group therapy sessions. Patients will be required to use the VR-CBT application at home approximately every two days, as well as attend three bi-weekly clinical check ins at the Precision NeuroClinics over a period of six weeks.

RSV is a common cause of respiratory tract infection, which involves the passage formed by the mouth, nose, throat, and lungs. It is contagious and can be easily spread. Vaccines prepare your immune system for fighting illnesses by causing your body to make antibodies. Antibodies are special proteins in the blood that help to protect you from infectious diseases caused by bacteria and viruses. This is a Phase 3 clinical trial to study the investigational vaccine called mRNA-1345, for the prevention of RSV. It has not yet been approved by Health Canada. The main goals of this trial are to understand the safety and tolerability of the trial vaccine.

Cardiovascular disease is common among people with kidney failure. Though often not recognized, these circulatory problems often affect the blood vessels of the legs resulting in difficulty walking, foot wounds, and in some cases, amputation. However, we do not have accurate screening tests to identify circulatory problems at an early stage, before complications develop. We propose that the smaller blood vessels in the muscle could be tested to detect circulatory problems before complications develop. Before we test whether these novel tests can prevent complications from poor leg circulation, we will first use this study to see if these tests are acceptable to patients and practical to do.

Interstitial Cystitis/Bladder Pain Syndrome (ICBPS) is a long lasting condition that includes bladder pain and the need to urinate often. Women with ICBPS often have sleep issues, social isolation and depression. Accessible health education can lower stress, improve communication and guide patient choices. It is a recommended first-line treatment strategy for ICBPS. Our study goal is to co-create health educational tools with women who have ICBPS. The project will have three focus group discussions. We will learn about their experiences and opinions on creating effective educational materials for ICBPS. This information will be used to co-create a draft of an educational tool that is relatable, realistic and relevant.

COVID-19 has had a significant impact on the lives of many Albertans. Even in those who recover from acute illness, many go on to suffer from lingering persistent symptoms, known as Long COVID, where currently there is no cure. In this study, we aim to improve understanding of why only some people develop long COVID and why some people develop more severe symptoms than others. To do so, we will look for specific blood and COVID-19 antibody markers in patients post COVID-19. This information will provide an understanding of the mechanisms associated with long COVID, which may reveal factors that contribute to long COVID development. With this knowledge, future treatment may then be possible to target the underlying cause of long COVID.