Although, there are many common symptoms that occur with chronic conditions, there is a lot of variation in the supportive care these patients receive. Their care is fragmented and uncoordinated, and may not reflect their wishes. To improve care for patients with chronic conditions there needs to be a standardized approach to better coordinate services no matter where they live in the province. Small focus groups and interview will be held to co-develop and integrated supportive care pathway for patients with chronic disease.

Infections of the heart (endocarditis) are common in patients with inborn heart defects (congenital heart disease).  Endocarditis may cause stroke, heart attack, heart failure, emergency surgery or death.  This study will gather data to better understand endocarditis in adult congenital heart patients.  The charts of patients with congenital heart disease and endocarditis  will be reviewed in order to gather data on risk factors, complications and adverse events.  This information will be valuable to understand who is most at risk of endocarditis and what the outcomes are after an episode of endocarditis. Ultimately it is hoped that information from this study will help patients and doctors better prevent and treat endocarditis.

Sanctuary trauma in psychiatric nursing is a serious issue linked to moral injury, burnout, PTSD, and workplace violence. Healthcare environments, meant to be healing spaces, can instead cause psychological distress for employees. Organizational support and strong leadership are crucial, but their relationship to sanctuary trauma is not well understood. The Sanctuary Model promotes psychological safety, emotional intelligence, and shared governance. The COVID-19 pandemic highlighted the need for change. Our research aims to understand sanctuary trauma in psychiatric nursing and explore staff perceptions of organizational support to create trauma-informed workplaces.

This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life. It will compare transcutaneous spinal cord stimulation and paired corticospinal-motoneuronal stimulation, both combined with rehabilitation. Using a crossover design, participants will receive each therapy for two months, with a washout period in between. Safety, effectiveness, and patient-reported outcomes like daily living ability and quality of life will be assessed, alongside changes in neural excitability. Our goal is to tailor treatments to individual needs, promoting personalized care and improved outcomes.

Heart disease is a common and serious medical condition which causes nearly one in every three deaths in Canada every year. We are well-aware of the factors which increase people’s risk for heart disease, but need to give people more support to reduce their risk of heart disease. Pharmacists are respected health professionals who are often easier to see than physicians, and can help people reduce their risk of heart disease. This research project aims to see whether a pharmacy service can help people reduce their risk of heart disease. The potential impact of this project is to empower people to understand how to reduce their risk of heart disease and reduce the burden of heart disease on the community.

Military members, veterans, first responders, public safety personnel, and healthcare professionals face numerous stressors and experience potentially traumatic events in the line of duty. They are at greater risk of developing operational stress injuries (OSIs) including post-traumatic stress disorder (PTSD), post-traumatic stress injuries (PTSIs), moral injury (MI), and related mental health conditions. Multi-modal Motion-assisted Memory Desensitization and Reconsolidation (3MDR) therapy is a promising intervention for these conditions that utilizes a virtual reality environment. This study is evaluating the effectiveness of 3MDR for trauma-affected populations (TAPs) from the groups listed above.

The Canadian Acromegaly Registry (CAR) will serve to connect Canadian patients with physicians and researchers. Participation in the CAR will help researchers to develop projects and learn more about acromegaly and enable patients to be kept informed about upcoming research opportunities.

We are exploring how spinal cord stimulation affects the nervous system in individuals with spinal cord injury and those who have suffered a stroke. We will first determine how stimulation parameters will affect outcomes, and then we will determine whether the combination of stimulation and rehabilitation can improve motor recovery in the arms and hands in these two patient populations.

SOS-AMI is a global phase 3 research study for people who have experienced one or more heart attacks and are at risk of experiencing heart attack(s) again in the future. The study will assess whether an investigational drug called selatogrel can treat a heart attack when self-administered by participants using a study autoinjector. All participants in the SOS-AMI study will receive training on how and when to use the study autoinjector, as well as regular follow-ups with the study team.

Up to 20 sites in the US & 4 sites in Canada will enroll 3,500 participants into this study registry & bio-repository. They will be enrolled into 1 of 4 Lupus Cohorts (groups). Most of the data collected will be collected from participants medical records. Participants will complete questionnaires on-line, using the clinic computer or their own computer from home. This registry does NOT provide medications. Blood, urine, saliva & stool samples are collected at each visit and sent to the bio-repository in the US for future research. They will not be tested immediately. Results will not be available to participants. The data & bio-samples will be kept by the Lupus Research Alliance for at least 15 years.