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Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)

Mild Cognitive Impairment | Vascular Cognitive Impairment

People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or "primed" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    50 and up

Participation Criteria

Inclusion Criteria:

* ≥50 years of age; females must be post-menopausal
* Presence of cerebrovascular and/or cardiovascular risk factors or coronary artery disease
* Montreal Cognitive Assessment (MoCA) \<27
* Sufficiently proficient in English
* Must be able to exercise at a moderate intensity level
* Presence of modest deficits (1 standard deviation below population norm) in one of the following domains: executive function, verbal memory, working memory, or visuospatial memory

Exclusion Criteria:

* History of stroke
* Change in psychotropics within the last 4 weeks
* Current benzodiazepine use due
* Metal implants that would preclude safe use of tDCS or neuroimaging
* Significant neurological or psychiatric conditions (current major depressive disorder, bipolar disorder, schizophrenia)
* MoCA \<18 and/or clinical diagnosis of dementia
* Any medical contraindications to exercise

Study Location

Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Mehreen Siddiqui

[email protected]
416-480-6100
Study Sponsored By
Sunnybrook Health Sciences Centre
Participants Required
More Information
Study ID: NCT05079464