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Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein

Obesity | Diabetes | Appetite Regulation | Satiety Response | Glycemic Control

The proposed study aims to simulate a meal eaten at home, where meals will provide a fixed amount of protein from beef or vegetarian substitute "meat" balls with ad libitum access to one of mashed potatoes, full-fat fries, or pasta. Postprandial glycemia (PPG), insulin, active ghrelin, satiety, amino acid response and food intake (FI) at the meal and again 3h later (after an ad libitum pizza meal) will be measured. In addition, post-meal PPG and satiety will be measured for one hour after the second meal.

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Participation Requirements

  • Sex:

    ALL
  • Eligible Ages:

    18 to 45

Participation Criteria

Inclusion Criteria:

* \> 18 and \< 45 years of age
* BMI \> 18.5 and \< 24.9 kg/m2
* Willing to maintain habitual diet, physical activity pattern, and body weight throughout the study.
* Willing to maintain current dietary supplement use throughout the study. On test days, subject agrees not to take any dietary supplements until dismissal from the Nutrition Intervention Center. Failure to comply will result in a rescheduled test visit.
* Willing to abstain from alcohol consumption for 24h prior to all test visits.
* Willing to refrain from marijuana/ edibles use for the duration of the study (approximately 6 weeks).
* Willing to avoid vigorous physical activity for 24h prior to all test visits.
* Understanding the study procedure and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator.

Exclusion Criteria:

* Smoking
* Thyroid problems
* Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, a malabsorptive syndrome, pancreatitis, gallbladder or biliary disease.
* Presence of a gastrointestinal disorder or surgeries within the past year.
* Known to be pregnant or lactating.
* Unwillingness or inability to comply with the experimental procedures and to follow our safety guidelines.
* Known intolerances, sensitivity or allergy to any ingredients in the study products.
* Extreme dietary habits (i.e Atkins diet, very high protein diets, etc.) or restrained eaters, identified by a score of ≥ 11 on the Eating Habits Questionnaire
* Uncontrolled hypertension (systolic blood pressure \> 140 mm Hg or diastolic blood pressure \> 90 mm Hg) as defined by the average blood pressure measured at screening.
* Weight gain or loss of at least 10lbs in previous three months.
* Excessive alcohol intake (more than 2 drinks per day or more than 9 drinks per week).
* Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect blood glucose or that could affect the outcome of the study as per investigator's judgment.

Study Location

University of Toronto - Department of Nutritional Sciences
University of Toronto - Department of Nutritional Sciences
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Amira Amr, PhD

[email protected]
6478645258
Backup Contact

Hrvoje Fabek, PhD

[email protected]
(416) 978-0799
Study Sponsored By
University of Toronto
Participants Required
More Information
Study ID: NCT05610124