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Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

Aortic Stenosis | Aortic Valve Stenosis

The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    0 and up

Participation Criteria

Inclusion Criteria:

* Echocardiographic transaortic mean gradient ≥ 20mmHg OR VARC-3 criteria for ≥ moderate hemodynamic valve deterioration post TAVR on any TTE \> 1 month post-TAVR
* Consensus by the Heart Team that the patient is suitable for Standardized Invasive Hemodynamics (SIH).

Exclusion Criteria:

* CT demonstrating leaflet thrombosis or hypoattenuated leaflet thickening (HALT)

Study Location

McMaster University
McMaster University
Hamilton, Ontario
Canada

Contact Study Team

Primary Contact

Tej Sheth, MD

St. Paul's Hospital
St. Paul's Hospital
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Elizabeth Grieve

604-682-2344
Vancouver General Hospital
Vancouver General Hospital
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Celine Yan

[email protected]
604 875 5120
Study Sponsored By
University of British Columbia
Participants Required
More Information
Study ID: NCT04827238