Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles
Obesity, Abdominal | Diabete Type 2The proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite production from a meal sequence rich in saturated fatty acids (SFA) or the same meals but rich in polyunsaturated fatty acids (PUFA) in individuals with or without obesity and Type 2 diabetes (T2D)
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Participation Requirements
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Sex:
ALL -
Eligible Ages:
45 to 65
Participation Criteria
Inclusion Criteria:
* Men and women aged between 45 and 65 years, menopaused women ;
* Body mass index between 20 to 35 kg/m² ;
* General good health ;
* Score of diet quality (HEI) between 40 and 70 ;
* Computer and Internet access ;
* Basic understanding of written French ;
* Daily stool frequency.
Exclusion Criteria:
* Intestinal pathologies including inflammatory bowel disease and gastrointestinal cancers ;
* Alcohol consumption greater than 15 portions for men and 10 for women weekly.
* Active tobacco and cannabis usage ;
* Consumption of omega-3 dietary supplements ;
* Consumption of dietary supplements (vitamins and probiotics) - must be ceased 2 weeks before the dietary intervention ;
* Completion of a course of antibiotics in the past 3 months ;
* Important weight change (+/- 5 kg) in the past 6 months ;
* Type 1 diabetes or insulin-treated diabetes.
Study Location
Institut sur la nutrition et les aliments fonctionnels - INAF
Institut sur la nutrition et les aliments fonctionnels - INAFQuébec, Quebec
Canada
Contact Study Team
- Study Sponsored By
- Laval University
- Participants Required
- More Information
- Study ID:
NCT05917132