Early Videocapsule Endoscopy for Upper Gastrointestinal Bleeding
Small Bowel BleedingThe objective of this study is to determine whether early video capsule endoscopy (VCE) immediately after a negative gastroscopy in the setting of suspected upper gastrointestinal bleeding (UGIB) improves patient outcomes as compared to the standard approach which typically involves performing colonoscopy prior to small bowel investigations. We aim to examine the differences in diagnostic yield, total number of procedures, length of hospitalization, mortality rates, and healthcare cost between the two groups.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 to 90
Participation Criteria
Inclusion Criteria:
* Age ≥ 18 years
* New onset of acute gastrointestinal bleeding defined as:
1. The presence of melena/maroon stool on physical exam OR history of melena/maroon stool within 48 hours of emergency room presentation PLUS
2. Hemoglobin drop of ≥ 20 g/L from patient's baseline
* Have capacity to consent
* Hemodynamically stable (i.e. blood pressure \>100/60 or pulse \<110 at the time of consent)
* Initial gastroscopy negative for active bleeding or potential bleeding source
Exclusion Criteria:
* Inability to provide consent due to lack of capacity, language barrier or other reasons
* Pregnant women
* Prior history of small bowel surgery
* Prior history of Crohn's disease
* Prior history of small bowel or colonic strictures
* Prior history of abdominal radiation
Study Location
University of Alberta Hospital
University of Alberta HospitalEdmonton, Alberta
Canada
Contact Study Team
- Study Sponsored By
- University of Alberta
- Participants Required
- More Information
- Study ID:
NCT05108844