NC Testing in LC & POTS
Postural Orthostatic Tachycardia Syndrome | Post Acute Sequelae of SARS CoV 2 InfectionPatients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 to 60
Participation Criteria
Inclusion Criteria:
* Patients with diagnosis of Long COVID
* SARS-COV2 test positive
* Symptoms \> 12 weeks post COVID
* Subjective complaint of 'brain fog" or cognitive dysfunction
* Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
* Subjective complaint of 'brain fog" or cognitive impairment
* Healthy participants
* Without POTS or "brain fog"
* Age 18 to 60 years
* Female and Male
* Able to give an informed consent
Exclusion Criteria:
* Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
* An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
* Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
* Unable to give an informed consent.
Study Location
University of Calgary
University of CalgaryCalgary, Alberta
Canada
Contact Study Team
- Study Sponsored By
- University of Calgary
- Participants Required
- More Information
- Study ID:
NCT05914649