Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
Cardiovascular Diseases | Kidney Transplantation | End Stage Renal Disease | Dialysis Related ComplicationThe Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.
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Participation Requirements
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Sex:
ALL -
Eligible Ages:
18 and up
Participation Criteria
Inclusion Criteria:
1. adults aged 18 years of age or older
2. Dialysis-dependent kidney failure and currently being assessed for OR active on the kidney transplant waiting list
3. expected to require further screening for CAD prior to transplantation (by current standard of care);
4. able to give consent;
5. anticipated to undergo transplantation more than 12 months from date of enrolment
Exclusion Criteria:
1. patients with signs or symptoms suggestive of uncontrolled cardiac disease such as unstable coronary syndromes, decompensated heart failure, uncontrolled arrhythmia, and severe valvular heart disease;
2. patients who "on-hold" for transplantation due to a medical problem;
3. patients with other solid organ transplants;
4. multi-organ transplant candidates (e.g. kidney-pancreas transplant candidates);
5. patients with planned living donor transplant;
6. patients unable to give consent.
Study Location
University of British Columbia
University of British ColumbiaVancouver, British Columbia
Canada
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London Health Science Centre
London Health Science CentreLondon, Ontario
Canada
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CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec
CHU de Quebec-Universite Laval's L'Hotel-Dieu de QuebecLaval, Quebec
Canada
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St. Paul's Hospital, University of Saskatchewan
St. Paul's Hospital, University of SaskatchewanSaskatoon, Saskatchewan
Canada
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University of Alberta
University of AlbertaEdmonton, Alberta
Canada
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Kingston Health Science Centre
Kingston Health Science CentreKingston, Ontario
Canada
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St Michael's Hospital
St Michael's HospitalToronto, Ontario
Canada
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Universite de Montreal, Hopital Maisonneuve-Rosemont
Universite de Montreal, Hopital Maisonneuve-RosemontMontréal, Quebec
Canada
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Dalhousie University
Dalhousie UniversityHalifax, Nova Scotia
Canada
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The Ottawa Hospital Research Institute
The Ottawa Hospital Research InstituteOttawa, Ontario
Canada
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University of Montreal, Maisonneuve-Rosemont Hospital
University of Montreal, Maisonneuve-Rosemont HospitalMontréal, Quebec
Canada
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St. Joseph's Healthcare
St. Joseph's HealthcareHamilton, Ontario
Canada
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University Health Network
University Health NetworkToronto, Ontario
Canada
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McGill University Health Centre
McGill University Health CentreMontréal, Quebec
Canada
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- Study Sponsored By
- University of British Columbia
- Participants Required
- More Information
- Study ID:
NCT03674307