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pEEG Monitoring Effect on Delirium, Ventilator Days, and PICS

Analgesia | Mechanical Ventilation Complication | Delirium | Critical Illness | Post Intensive Care...

The goal of this multi-site observational study is to compare delirium rates, days on mechanical ventilation, and Post Intensive Care Syndrome (PICS) rates in adult Intensive Care Unit (ICU) patients. The study will examine patients whose sedation and analgesia infusion titration is managed with both Richmond Agitation and Sedation Scale (RASS) and Processed Electroencephalography (pEEG) monitoring vs patients who receive RASS monitoring alone.

The main questions are:

* Compared to RASS monitoring method alone, does the use of 4 channel pEEG monitor in conjunction with RASS to guide the management of sedation and analgesic in patients who are ventilated reduce the average number of delirium days, measured by Intensive Care Delirium Screening Checklist (ICDSC)?
* To determine when compared to RASS monitoring alone if the use of 4 channel pEEG monitor in conjunction with RASS to guide the management of Intravenous (IV) sedation and analgesia in ventilated patients reduces the days a patient spends on a mechanical ventilator when compared to RASS only monitoring from retrospective data.
* To determine when compared to RASS monitoring method alone, does the use of 4 channel pEEG monitor in conjunction with RASS experience lower doses of sedation and analgesia infusions?
* To determine when compared to RASS monitoring method alone, does the use of 4 channel pEEG monitor in conjunction with RASS experience less incidence and duration of PICS?

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    17 and up

Participation Criteria

Inclusion Criteria:

1. Admitted to ICU
2. Receive mechanical ventilator support during ICU stay
3. Require IV sedation or analgesic while ventilated
4. Discharged home from the hospital
5. Use of pEEG for sedation or analgesic titration
6. Able to read and speak English
7. Mechanically ventilated greater than 48 hours
8. Aged 17 years +1 day or greater
9. Consent to participate
10. Participants need a computer with a keyboard, internet access, and email access for the questionnaires and assessment and be able to use computer and internet.

Exclusion Criteria:

1. Deceased during hospitalization
2. Intubated at a hospital not included within the study \> 12 hours
3. Discharge to rehabilitation facility, long term care, or other outpatient setting
4. Inability to provide informed consent
5. Currently enrolled in any other research study involving drugs or devices
6. Is unable to be screened for delirium during ICU admission.

Study Location

Abbotsford Regional Hospital
Abbotsford Regional Hospital
Abbotsford, British Columbia
Canada

Contact Study Team

Primary Contact

Fiona Howarth

[email protected]
60480717066043694
Study Sponsored By
Fraser Health
Participants Required
More Information
Study ID: NCT06019078