CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
Cancer | Cancer, Therapy-Related | Malignant Solid Tumor | Malignancies Multiple | Molecular Sequence...This study will collect data on Canadian cancer patients that have uncommon/rare changes in their tumours, such as alterations/rearrangements in the genetic material inside cells - known as deoxyribonucleic acid, or DNA, which acts as a map and gives directions to the cells on how to make other substances the body needs - because some of these changes have been found to respond to different drugs that help to stop the cancer. These rare changes occur in genes such as but not limited to ALK, EGFR, ROS1, BRAF, and NTRK which have targeted drugs in a family known as tyrosine kinase inhibitors (TKIs), and KRAS G12C mutation, which now has a targeted inhibitor drug therapy for patients with non small cell lung cancer (NSCLC). The goals for the study are to compare the natural history of such cancers and the treatment outcomes, including toxicities and patient-reported outcomes, for the different therapies.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 and up
Participation Criteria
Inclusion Criteria:
* Patients ≥ 18 years at cancer diagnosis
* Diagnosed with malignant tumour(s) with molecular testing completed that identified rare molecular alterations
* Accessible/available molecular testing reports/documentation to confirm type(s) of molecular alteration(s) (resulting from the conduct of polymerase chain reaction \[PCR\] based next generation sequencing \[NGS\], immunohistochemistry \[IHC\], fluorescence in situ hybridization \[FISH\], liquid biopsy)
* Canadian resident received follow-up for cancer care in Canada or is currently receiving/planning follow-up for cancer care to occur in Canada at time of enrollment
Exclusion Criteria:
* Previous refusal of the deceased patient, when living, to enroll in this study or patient approached for this study is unable to provide informed consent
Study Location
Tom Baker Cancer Centre - University of Calgary - Alberta Health Services
Tom Baker Cancer Centre - University of Calgary - Alberta Health ServicesCalgary, Alberta
Canada
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Dr. Everett Chalmers Regional Hospital
Dr. Everett Chalmers Regional HospitalFredericton, New Brunswick
Canada
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Hamilton Health Sciences - Juravinski Cancer Centre
Hamilton Health Sciences - Juravinski Cancer CentreHamilton, Ontario
Canada
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Health Sciences North
Health Sciences NorthSudbury, Ontario
Canada
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Sunnybrook Research Institute - Sunnybrook Health Sciences Centre
Sunnybrook Research Institute - Sunnybrook Health Sciences CentreToronto, Ontario
Canada
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McGill University Health Centre
McGill University Health CentreMontréal, Quebec
Canada
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Centre hospitalier universitaire de Sherbrooke (CHUS)
Centre hospitalier universitaire de Sherbrooke (CHUS)Sherbrooke, Quebec
Canada
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CancerCare Manitoba/University of Manitoba
CancerCare Manitoba/University of ManitobaWinnipeg, Manitoba
Canada
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William Osler Health System - Brampton Civic Hospital
William Osler Health System - Brampton Civic HospitalBrampton, Ontario
Canada
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Ottawa Hospital Cancer Centre
Ottawa Hospital Cancer CentreOttawa, Ontario
Canada
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Mount Sinai Hospital
Mount Sinai HospitalToronto, Ontario
Canada
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Jewish General Hospital
Jewish General HospitalMontréal, Quebec
Canada
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Institut Universitaire de Cardiologie et de Pneumologie de Québec
Institut Universitaire de Cardiologie et de Pneumologie de QuébecQuébec City, Quebec
Canada
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Cross Cancer Institute, University of Alberta - Alberta Health Services
Cross Cancer Institute, University of Alberta - Alberta Health ServicesEdmonton, Alberta
Canada
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Dr. H. Bliss Murphy Cancer Centre
Dr. H. Bliss Murphy Cancer CentreSaint John's, Newfoundland and Labrador
Canada
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Kingston Health Sciences Centre (KHSC)
Kingston Health Sciences Centre (KHSC)Kingston, Ontario
Canada
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Thunder Bay Regional Health Sciences Centre
Thunder Bay Regional Health Sciences CentreThunder Bay, Ontario
Canada
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Centre hospitalier de l'Université de Montréal (CHUM)
Centre hospitalier de l'Université de Montréal (CHUM)Montréal, Quebec
Canada
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St. Mary's Hospital Center
St. Mary's Hospital CenterMontréal, Quebec
Canada
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Allan Blair Cancer Centre
Allan Blair Cancer CentreRegina, Saskatchewan
Canada
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BC Cancer
BC CancerVancouver, British Columbia
Canada
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Queen Elizabeth II (QEII) Health Sciences Centre
Queen Elizabeth II (QEII) Health Sciences CentreHalifax, Nova Scotia
Canada
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Lawson Health Research Institute - London Health Sciences Centre
Lawson Health Research Institute - London Health Sciences CentreLondon, Ontario
Canada
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Princess Margaret Cancer Centre (PMCC) - University Health Network (UHN)
Princess Margaret Cancer Centre (PMCC) - University Health Network (UHN)Toronto, Ontario
Canada
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Hôpital du Sacré-Coeur-de-Montréal (HSCM)
Hôpital du Sacré-Coeur-de-Montréal (HSCM)Montréal, Quebec
Canada
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Centre hospitalier de l'université de Québec - Université Laval
Centre hospitalier de l'université de Québec - Université LavalQuébec City, Quebec
Canada
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Saskatoon Cancer Centre
Saskatoon Cancer CentreSaskatoon, Saskatchewan
Canada
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- Study Sponsored By
- University Health Network, Toronto
- Participants Required
- More Information
- Study ID:
NCT04151342