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Extended-Release Tacrolimus Following Liver Transplantation

Cardiovascular Diseases | Metabolic Syndrome | Renal Insufficiency | Liver Transplant;...

Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or confusion; high blood pressure; anemia, or low blood cell counts; diabetes; abnormal cholesterol and weight gain. The investigators want to use a new, approved, formulation of the standard medication (Envarsus) as they believe it may be associated with reduced side effects. The investigators would like to assess how safe it is to use this medication and how well it works in comparison to currently used formulations. The investigators will study if there are less side effects and will study clinical outcomes (including how well the liver does and if there is need for hospitalizations after transplant).

The investigators hope that this information will improve the care provided to and outcomes in patients following liver transplant.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

- Adult individuals transplanted at the University of Alberta

Exclusion Criteria:

* Individuals with congenital long QT syndrome
* Patients with elevated bilirubin \> 100 umol/L post-LT (at day 3)
* Patients with chronic kidney disease (eGFR \< 45 ml per minute per 1.73 m2)
* Patients with acute kidney injury requiring discontinuation of calcineurin inhibitors.
* Patients who require a re-transplant, or receive multi-visceral transplant

Study Location

Univerity of Alberta
Univerity of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Rahima Bhanji, MD

[email protected]
780-492-2235
Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: NCT05242315