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DOTATOC PET/CT for Imaging NET Patients

Pheochromocytoma | Paraganglioma | Neuroendocrine Tumors | Meningioma | Neuroblastoma | Small-Cell Lung...

Neuroendocrine tumours (NETs) are generally slow growing, but some can be aggressive and resistant to treatment. Compared to healthy cells, the surface of these tumor cells has a greater number of special molecules called somatostatin receptors (SSTR). Somatostatin receptor scintigraphy and conventional imaging are used to detect NETs.

This study proposes 68Gallium(68Ga)-DOTATOC positron emission tomography/computed tomography (PET/CT) is superior to current imaging techniques. The goal is to evaluate the safety and sensitivity of 68Ga-DOTATOC PET/CT at detecting NETs and other tumors with over-expression of somatostatin receptors.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

All subjects:

* World health organization performance status 0-2
* Able to provide written informed consent/assent (or consent by guardian for subjects \<19 years)
* Patients must be able to tolerate the physical/logistical requirements of completing a PET scan including lying flat for up to 30 minutes and tolerating intravenous cannulation for injection.

Patients must require imaging for either staging or re-staging of:

* Gastroenteropancreatic tumors (e.g. carcinoids, gastrinoma, insulinoma, glucagonoma, VIPoma, etc.), functioning and non-functioning
* Sympathoadrenal system tumors (phaeochromocytoma, paraganglioma, neuroblastoma, ganglioneuroma)
* Medullary thyroid carcinoma
* Pituitary adenoma
* Medulloblastoma
* Merkel cell carcinoma
* Small-cell lung cancer (mainly primary tumors)
* Meningioma
* Or any other NET / with potential for overexpression of SSTR

Exclusion Criteria:

* Pregnancy
* Patients who are medically unstable ex: acute cardiac or respiratory distress, hypotensive
* Patients who exceed the safe weight limit of the PET/CT bed (204.5 kg) or who cannot fit through the PET/CT bore (diameter 70cm).

Study Location

BC Cancer
BC Cancer
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Research Project Manager

[email protected]
604-8675-8000
Study Sponsored By
British Columbia Cancer Agency
Participants Required
More Information
Study ID: NCT03583528