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Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse

Healthy | Skeletal Muscle Atrophy | Skeletal Muscle Hypertrophy

Skeletal muscle plays a critical role in supporting human health. Beyond its role in providing the force to move, skeletal muscle accounts for a large proportion of metabolic rate, glucose disposal, and amino acid storage. Skeletal muscle is dynamically regulated by environmental stimuli, such as loading (i.e., resistance training\]) and unloading (i.e., disuse atrophy) as well as the intake of essential amino acids (EAAs). However, the precise mechanisms that regulate skeletal muscle mass in response to various conditions (e.g., EAA supplementation, resistance training, and unloading) are not completely understood. Therefore, concerted efforts to better understand the mechanisms regulating skeletal muscle size are needed that aid in the development of therapeutic interventions to combat age, disease, and disuse related muscular atrophy.

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    18 to 30

Participation Criteria

Inclusion Criteria:

* Females 18-30 years
* BMI between 18-28 kg/m2
* ≥2 days per week of structured exercise
* Generally healthy as assessed by medical and physical activity questionnaires
* Participants not currently pregnant

Exclusion Criteria:

* Any muscular, neurological, respiratory, or metabolic disease including diabetes
* Any form of cancer currently or in the last 5 years
* Bleeding disorders or antiplatelet / anticoagulation therapy
* Currently taking fish oils or within the last 6 months
* Currently taking any form of steroid or within the last 3 months
* Inability to attain magnetic resonance imaging scans
* Known irregular responses to physical activity (e.g., shortness of breath, chest pain, dizziness, etc.)
* Any current illness
* Currently smoking or smoking within the last 6 months
* Currently pregnant
* Any concurrent medical, psychiatric, or orthopedic condition that, subject to investigators' discernment, would negatively affect the subject's ability to comply with the study requirements

Study Location

School of Kinesiology and Health Studies
School of Kinesiology and Health Studies
Kingston, Ontario
Canada

Contact Study Team

Backup Contact

Chris McGlory, PhD

Backup Contact

Kristine Boileau, BSc

[email protected]
Primary Contact

Chris McGlory, PhD

[email protected]
6135336000
Study Sponsored By
Queen's University
Participants Required
More Information
Study ID: NCT06350591